Desktop Helper 2 - REFERENCES with links

26 Apr 2024
  1. Venkatesan P. 2023 GINA report for asthma. Lancet Respir Med.2023 Jul;11(7):589. doi: 10.1016/S2213-2600(23)00230-8.Epub 2023 Jun 8.
  2. Ryan D, Heatley H, Heaney LG, Jackson DJ, Pfeffer PE, Busby J, Menzies-Gow AN, Jones R, Tran TN, Al-Ahmad M, Backer V, Belhassen M, Bosnic-Anticevich S, Bourdin A, Bulathsinhala L, Carter V, Chaudhry I, Eleangovan N, FitzGerald JM, Gibson PG, Hosseini N, Kaplan A, Murray RB, Rhee CK, Van Ganse E, PriceDB. Potential Severe Asthma Hidden in UK Primary Care. JAllergy Clin Immunol Pract. 2021 Apr;9(4):1612-1623.e9. doi:10.1016/j.jaip.2020.11.053. Epub 2020 Dec 9. Erratum in: JAllergy Clin Immunol Pract. 2021 Nov;9(11):4182.
  3. João C, Jácome C, Brito D, Teixeira P, Quelhas-Santos J, Amorim L, Barbosa MJ, Bulhões C, Lopes F, Pardal M, BernardoF, Fonseca JA, Correia de Sousa J. Prevalence and Characterisation of Patients with Asthma According to Disease Severity in Portugal: Findings from the EPI-ASTHMA Pilot Study. JAsthma Allergy. 2022 Oct 19;15:1441-1453. doi:10.2147/JAA.S381716.
  4. Barry LE, Sweeney J, O'Neill C, Price D, Heaney LG. The cost of systemic corticosteroid-induced morbidity in severe asthma: a health economic analysis. Respir Res. 2017 Jun 26;18(1):129.doi: 10.1186/s12931-017-0614-x.
  5. Inoue H, Kozawa M, Milligan KL, Funakubo M, Igarashi A, Loefroth E. A retrospective cohort study evaluating healthcare resource utilization in patients with asthma in Japan. NPJ PrimCare Respir Med. 2019 Apr 29;29(1):13. doi:10.1038/s41533-019-0128-8.
  6. Flórez-Tanus Á, Parra D, Zakzuk J, Caraballo L, Alvis-GuzmánN. Health care costs and resource utilization for different asthma severity stages in Colombia: a claims data analysis. WorldAllergy Organ J. 2018 Nov 12;11(1):26. doi:10.1186/s40413-018-0205-4.
  7. O'Neill S, Sweeney J, Patterson CC, Menzies-Gow A, Niven R, Mansur AH, Bucknall C, Chaudhuri R, Thomson NC, Brightling CE, O'Neill C, Heaney LG; British Thoracic Society Difficult Asthma Network. The cost of treating severe refractory asthma in the UK: an economic analysis from the British Thoracic Society Difficult Asthma Registry. Thorax. 2015 Apr;70(4):376-8. doi:10.1136/thoraxjnl-2013-204114. Epub 2014 Jun 10.
  8. Zhang Q, Wu WW, Li L, McDonald VM, Chen YC, Wang G, Gibson PG. Workup of difficult-to-treat asthma: implications from treatable traits. Precis Clin Med. 2023 Feb24;6(1):pbad003. doi: 10.1093/pcmedi/pbad003.
  9. Aaron SD, Vandemheen KL, FitzGerald JM, Ainslie M, Gupta S, Lemière C, Field SK, McIvor RA, Hernandez P, Mayers I, Mulpuru S, Alvarez GG, Pakhale S, Mallick R, Boulet LP; Canadian Respiratory Research Network. Reevaluation of Diagnosis in Adults With Physician-Diagnosed Asthma. JAMA. 2017 Jan 7;317(3):269-279. doi: 10.1001/jama.2016.19627.
  10. Heffler E, Pizzimenti S, Guida G, Bucca C, Rolla G. Prevalence of over-/misdiagnosis of asthma in patients referred to an allergy clinic. J Asthma. 2015;52(9):931-4. doi:10.3109/02770903.2015.1026442. Epub 2015 Aug 18.
  11. Heaney LG, Robinson DS. Severe asthma treatment: need for characterising patients. Lancet. 2005 Mar 12-18;365(9463):974-6. doi: 10.1016/S0140-6736(05)71087-4.
  12. Gillis RME, van Litsenburg W, van Balkom RH, Muris JW, Smeenk FW. The contribution of an asthma diagnostic consultation service in obtaining an accurate asthma diagnosis for primary care patients: results of a real-life study. NPJ Prim Care Respir Med. 2017 May 19;27(1):35. doi: 10.1038/s41533-017-0027-9.
  13. Starren ES, Roberts NJ, Tahir M, O'Byrne L, Haffenden R, Patel IS, Partridge MR. A centralised respiratory diagnostic service for primary care: a 4-year audit. Prim Care Respir J. 2012 Jun;21(2):180-6. doi: 10.4104/pcrj.2012.00013.
  14. Hashimoto S, Bel EH. Current treatment of severe asthma. Clin Exp Allergy. 2012 May;42(5):693-705. doi: 10.1111/j.1365- 2222.2011.03936.x. Epub 2012 Jan 18.
  15. Redmond C, Heaney LG, Chaudhuri R, Jackson DJ, Menzies- Gow A, Pfeffer P, Busby J; UK Severe Asthma Registry. Benefits of specialist severe asthma management: demographic and geographic disparities. Eur Respir J. 2022 Dec 15;60(6):2200660. doi: 10.1183/13993003.00660-2022.
  16. Global Initiative for Asthma. GINA Severe Asthma Guide 2023 [Internet]. 2023 . Available from:
  17. McDonald VM, Hiles SA, Godbout K, Harvey ES, Marks GB, Hew M, Peters M, Bardin PG, Reynolds PN, Upham JW, Baraket M, Bhikoo Z, Bowden J, Brockway B, Chung LP, Cochrane B, Foxley G, Garrett J, Jayaram L, Jenkins C, Katelaris C, Katsoulotos G, Koh MS, Kritikos V, Lambert M, Langton D, Lara Rivero A, Middleton PG, Nanguzgambo A, Radhakrishna N, Reddel H, Rimmer J, Southcott AM, Sutherland M, Thien F, Wark PAB, Yang IA, Yap E, Gibson PG. Treatable traits can be identified in a severe asthma registry and predict future exacerbations. Respirology. 2019 Jan;24(1):37-47. doi: 10.1111/resp.13389. Epub 2018 Sep 19.
  18. Zhang Q, Wu WW, Li L, McDonald VM, Chen YC, Wang G, Gibson PG. Workup of difficult-to-treat asthma: implications from treatable traits. Precis Clin Med. 2023 Feb 24;6(1):pbad003. doi: 10.1093/pcmedi/pbad003.
  19. McDonald VM, Clark VL, Cordova-Rivera L, Wark PAB, Baines KJ, Gibson PG. Targeting treatable traits in severe asthma: a randomised controlled trial. Eur Respir J. 2020 Mar 5;55(3):1901509. doi: 10.1183/13993003.01509-2019. PMID: 31806719.
  20. Simpson AJ, Hekking PP, Shaw DE, Fleming LJ, Roberts G, Riley JH, Bates S, Sousa AR, Bansal AT, Pandis I, Sun K, Bakke PS, Caruso M, Dahlén B, Dahlén SE, Horvath I, Krug N, Montuschi P, Sandstrom T, Singer F, Adcock IM, Wagers SS, Djukanovic R, Chung KF, Sterk PJ, Fowler SJ; U-BIOPRED Study Group. Treatable traits in the European U-BIOPRED adult asthma cohorts. Allergy. 2019 Feb;74(2):406-411. doi:10.1111/all.13629. Epub 2018 Nov 12.
  21.  Tay TR, Hew M. Comorbid "treatable traits" in difficult asthma: Current evidence and clinical evaluation. Allergy. 2018 Jul;73(7):1369-1382. doi: 10.1111/all.13370. Epub 2017Dec 15.
  22. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention 2023 [Internet]. 2023. Available from:
  23. Ryan D, Murphy A, Ställberg B, Baxter N, Heaney LG. 'SIMPLES': a structured primary care approach to adults with difficult asthma. Prim Care Respir J. 2013 Sep;22(3):365-73. doi: 10.4104/pcrj.2013.00075.
  24. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention 2023 [Internet]. 2023. Available from:
  25. Borrego LM, Fonseca JA, Pereira AM, Pinto VR, Linhares D, Morais-Almeida M. Development process and cognitive testing of CARAT kids - Control of Allergic Rhinitis and Asthma Test for children. BMC Pediatr. 2014 Feb 6;14:34. doi: 10.1186/1471- 2431-14-34.
  26. Tiotiu A, Ioan I, Wirth N, Romero-Fernandez R, González- Barcala FJ. The Impact of Tobacco Smoking on Adult Asthma Outcomes. Int J Environ Res Public Health. 2021 Jan 23;18(3):992. doi: 10.3390/ijerph18030992.
  27. To T, Daly C, Feldman R, McLimont S. Results from a community-based program evaluating the effect of changing smoking status on asthma symptom control. BMC Public Health. 2012 Apr 20;12:293. doi: 10.1186/1471-2458-12-293.
  28. Jenkins CR, Bateman ED, Sears MR, O'Byrne PM. What have we learnt about asthma control from trials of budesonide/formoterol as maintenance and reliever? Respirology. 2020 Aug;25(8):804-815. doi: 10.1111/resp.13804. Epub 2020 Mar 31. Erratum in:Respirology. 2020 Oct;25(10):1103-1104.
  29. Kumar M, Gupta RK, Kumar R, Spalgais S, Mavi AK, Singh K. Cockroach exposure and its allergy sensitization in asthma patients. Monaldi Arch Chest Dis. 2021 May 11;91(3). doi: 10.4081/monaldi.2021.1685.
  30. Volmer T, Effenberger T, Trautner C, Buhl R. Consequences of long-term oral corticosteroid therapy and its side-effects in severe asthma in adults: a focused review of the impact data in the literature. Eur Respir J. 2018 Oct 25;52(4):1800703. doi:10.1183/13993003.00703-2018.
  31. Blakey J, Chung LP, McDonald VM, Ruane L, Gornall J, Barton C, Bosnic-Anticevich S, Harrington J, Hew M, Holland AE, Hopkins T, Jayaram L, Reddel H, Upham JW, Gibson PG, Bardin P. Oral corticosteroids stewardship for asthma in adults and adolescents: A position paper from the Thoracic Society of Australia and New Zealand. Respirology. 2021 Dec;26(12):1112-1130. doi: 10.1111/resp.14147. Epub 2021 Sep 29.
  32. Robert Schellenberg, Jonathan D R Adachi, Dennis Bowie, Jacques Brown, Lyn Guenther, Tina Kader, Graham E Trope, "Oral Corticosteroids in Asthma: A Review of Benefits and Risks", Canadian Respiratory Journal, vol. 14, Article ID 160691, 7 pages, 2007.
  33. Levy ML, Hardwell A, McKnight E, Holmes J. Asthma patients' inability to use a pressurised metered-dose inhaler (pMDI) correctly correlates with poor asthma control as defined by the global initiative for asthma (GINA) strategy: a retrospective analysis. Prim Care Respir J. 2013 Dec;22(4):406-11. doi: 10.4104/pcrj.2013.00084.
  34. Severe Asthma Toolkit. Monoclonal Antibodies [Internet]. [cited 2024 Feb 20]. Available from:
  35. Wu AC, Butler MG, Li L, Fung V, Kharbanda EO, Larkin EK, Vollmer WM, Miroshnik I, Davis RL, Lieu TA, Soumerai SB. Primary adherence to controller medications for asthma is poor. Ann Am Thorac Soc. 2015 Feb;12(2):161-6. doi: 10.1513/AnnalsATS.201410-459OC.
  36. Plaza V, Giner J, Rodrigo GJ, Dolovich MB, Sanchis J. Errors in the Use of Inhalers by Health Care Professionals: A Systematic Review. J Allergy Clin Immunol Pract. 2018 May-Jun;6(3):987-995. doi: 10.1016/j.jaip.2017.12.032. Epub 2018 Jan 31.
  37. Virchow JC, Crompton GK, Dal Negro R, Pedersen S, Magnan A, Seidenberg J, Barnes PJ. Importance of inhaler devices in the management of airway disease. Respir Med. 2008Jan;102(1):10-9. doi: 10.1016/j.rmed.2007.07.031. Epub 2007 Oct 17.
  38. Global Initiative for Asthma. GINA Severe Asthma Guide 2023 [Internet]. 2023 [cited 2024 Feb 20]. Available from:
  39. Jahedi L, Downie SR, Saini B, Chan HK, Bosnic-Anticevich S. Inhaler Technique in Asthma: How Does It Relate to Patients' Preferences and Attitudes Toward Their Inhalers? J Aerosol Med Pulm Drug Deliv. 2017 Feb;30(1):42-52. doi: 10.1089/jamp.2016.1287. Epub 2016 Sep 27.
  40. Albassam A, Alharbi A, Awaisu A. Assessing Adherence to Inhaled Corticosteroids Among Adults with Asthma in Kuwait Using the Medication Adherence Report Scale for Asthma. Patient Prefer Adherence. 2020 Jun 9;14:963-970. doi: 10.2147/PPA.S248655.
  41. Selroos O, Borgström L, Ingelf J. Use of dry powder inhalers in acute exacerbations of asthma and COPD. Ther Adv Respir Dis. 2009 Apr;3(2):81-91. doi: 10.1177/1753465809103737. Epub 2009 May 14.
  42. Price DB, Román-Rodríguez M, McQueen RB, Bosnic-Anticevich S, Carter V, Gruffydd-Jones K, Haughney J, Henrichsen S, Hutton C, Infantino A, Lavorini F, Law LM, Lisspers K, Papi A, Ryan D, Ställberg B, van der Molen T, Chrystyn H. Inhaler Errors in the CRITIKAL Study: Type, Frequency, and Association with Asthma Outcomes. J Allergy Clin Immunol Pract. 2017 Jul- Aug;5(4):1071-1081.e9. doi: 10.1016/j.jaip.2017.01.004.Epub 2017 Mar 9.
  43. Althoff MD, Ghincea A, Wood LG, Holguin F, Sharma S. Asthma and Three Colinear Comorbidities: Obesity, OSA, and GERD. J Allergy Clin Immunol Pract. 2021 Nov;9(11):3877-3884. doi: 10.1016/j.jaip.2021.09.003. Epub 2021 Sep 8.
  44. Toennesen LL, Meteran H, Hostrup M, Wium Geiker NR, Jensen CB, Porsbjerg C, Astrup A, Bangsbo J, Parker D, Backer V. Effects of Exercise and Diet in Nonobese Asthma Patients-A Randomized Controlled Trial. J Allergy Clin Immunol Pract. 2018 May-Jun;6(3):803-811. doi: 10.1016/j.jaip.2017.09.028. Epub 2017 Nov 10.
  45. Walsted ES, Famokunwa B, Andersen L, Rubak SL, Buchvald F, Pedersen L, Dodd J, Backer V, Nielsen KG, Getzin A, Hull JH. Characteristics and impact of exercise-induced laryngeal obstruction: an international perspective. ERJ Open Res. 2021 Jun 28;7(2):00195-2021. doi: 10.1183/23120541.00195-2021.
  46. Pitzner-Fabricius A, Dall CH, Henriksen M, Hansen ESH, Toennesen LL, Hostrup M, Backer V. Effect of High-Intensity Interval Training on Inhaled Corticosteroid Dose in Asthma Patients: A Randomized Controlled Trial. J Allergy Clin Immunol Pract. 2023 Jul;11(7):2133-2143.e8. doi:10.1016/j.jaip.2023.04.013. Epub 2023 May 31.
  47. Semlitsch T, Stigler FL, Jeitler K, Horvath K, Siebenhofer A. Management of overweight and obesity in primary care- A systematic overview of international evidence-based guidelines. Obes Rev. 2019 Sep;20(9):1218-1230. doi:10.1111/obr.12889. Epub 2019 Jul 8.
  48. Gemesi K, Winkler S, Schmidt-Tesch S, Schederecker F, Hauner H, Holzapfel C. Efficacy of an app-based multimodal lifestyle intervention on body weight in persons with obesity: results from a randomized controlled trial. Int J Obes (Lond). 2024 Jan;48(1):118-126. doi: 10.1038/s41366-023-01415-0. Epub 2023 Nov 28.
  49. Stubbs MA, Clark VL, Gibson PG, Yorke J, McDonald VM. Associations of symptoms of anxiety and depression with health status, asthma control, dyspnoea, dysfunction breathing and obesity in people with severe asthma. Respir Res. 2022 Dec 12;23(1):341. doi: 10.1186/s12931-022-02266-5.
  50. Withers AL, Green R. Transition for Adolescents and Young Adults With Asthma. Front Pediatr. 2019 Jul 23;7:301. doi: 10.3389/fped.2019.00301.
  51. Porsbjerg C, Ulrik C, Skjold T, Backer V, Laerum B, Lehman S, Janson C, Sandstrøm T, Bjermer L, Dahlen B, Lundbäck B, Ludviksdottir D, Björnsdóttir U, Altraja A, Lehtimäki L, Kauppi P, Karjalainen J, Kankaanranta H. Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults. Eur Clin Respir J. 2018 Mar 6;5(1):1440868. doi: 10.1080/20018525.2018.1440868.

Resource information

Respiratory conditions
  • Asthma
  • Multi-morbidity
Respiratory topics
  • Co-morbidities
  • Difficult to manage asthma
  • Disease management
Type of resource
  • Asthma Right Care
Right Care
  • Asthma
Strategic Objective
  • Management
  • Risk Factors
  • When control is poor
  • Clinical Education

Right Care information