Open Science, Data, and Methodologies: Lessons learned from NIHR-RESPIRE Network in Asia

NIHR-RESPIRE, a Global Health Research Unit funded by NIHR, is committed to advancing respiratory health research in Asia. We prioritise Open Science, Data, and Methodologies to maximise research data utility securely, sharing the lessons encountered across seven LMIC partner countries (Bangladesh, Bhutan, India, Indonesia, Malaysia, Pakistan, and Sri Lanka). Our strategic shift from traditional data sharing to LMIC-tailored Open Science practices ensures data privacy and security. This includes refining Data Management Plans, metadata standards, and mandating FAIR Data sharing, providing methodological support, and developing Open Science Policy Guidelines. We advocate for the adoption of open science principles to maximise secure data use and value with a focus on FAIR data. We also provide aid to partners in enhancing their data-related skills, hosting regular meetings, and establishing internal data monitoring structures to bolster cross-cutting activities within RESPIRE. Through capacity building, we have enabled high-quality respiratory health research using Open Science principles, enhancing data sharing efficiency, research visibility, and ultimately respiratory health outcomes in Asia and beyond. Our experience underscores the following lessons: (1) Flexibility in data sharing, tailored to LMIC researchers' needs, is essential; (2) Training and support to enhance knowledge of methodologies and dispel misconceptions are key to successful data stewardship; (3) Appointing a focal person for structured anonymised data sharing and supporting the internal Data Monitoring Committee are critical. We recognise Open Science's potential to foster innovation, collaboration, and knowledge sharing in respiratory health research.